GLP-1 medications, such as Ozempic and Wegovy, have been referred to as weight loss “game-changers” or “miracles” for people living with obesity. A 2021 clinical trial found that 86.2% of more than 800 participants experienced significant weight loss after taking 2.4-milligram (mg) doses of semaglutide for 68 weeks. While that sounds promising, 13.8% of participants did not see clinically significant weight loss.
When it comes to GLP-1 medications, health experts state that people fall into two camps: responder or non-responder. The former indicates that people positively respond to the medications and experience weight loss, while the later indicates that the medications have no effect on the person. Just like with other medications, one prescription is not a one-size-fits-all remedy for every single person. That is especially true for managing obesity.
Doctors want to remind patients that there tends to be more than one reason why a person ends up in the responder or non-responder categories. Even though the drugs may seem ideal in clinical trials, they do not work for everyone. Just like other medications, they can be unpredictable, both in how they perform and how a person responds to them. Why is that the case? Continue reading to learn about five of the most common reasons, according to health experts.
Existing Medical Issues
It’s possible for a person to have underlying medical issues that are either untreated, undertreated, or undiagnosed. Hypothyroidism, sleep apnea, and chronic insomnia, for example, can all interfere with weight loss. Those conditions should be dealt with prior to starting a weight loss journey, let alone a weight loss medication. Patients who have an issue with obesity and a binge eating disorder should also address the eating disorder prior to using GLP-1 medications. The binge eating disorder will not correct itself just because you take a GLP-1.
Medication Interference
People who take GLP-1 drugs alongside other medications may experience less weight loss, or none at all. It’s common for people who take antidepressants and beta blockers to have a difficult time losing weight. Adding a GLP-1 drug to the mix will not encourage weight loss, though. It is better to speak to your healthcare provider about other medications prior to taking a GLP-1.
Insulin Resistance
Ozempic is a GLP-1 drug designed to help diabetics lower their A1C. According to a 2022 narrative review, though, people may lose less weight while taking GLP-1 medications. When you have a pre-existing metabolic disease, it can feel like an uphill battle to reverse those abnormalities, especially if you’ve lived with them for a long time. This is due to the physiological response. Typically, GLP-1 aids blood sugar control by stimulating the pancreas to release insulin after meals. That response may be less potent in individuals who do not have type 2 diabetes. The weakened response to GLP-1, then, can make it more difficult to manage blood sugar and lose weight, which can require alternative treatment methods.
Lifestyle Changes
Trials for semaglutide have included lifestyle intervention for both placebo and medication groups. In a 2021 trial consisting of more than 1,900 adults, for example, researchers wanted to see what influenced the best response to a GLP-1 medication. The general recommendation was that patients should:
- Exercise regularly
- Manage stress
- Maintain a predominantly plant-based diet
- Get quality sleep
- Avoid substance use
- Keep strong social relationships with family and friends
Now, those recommendations are not novel in regards to losing weight and living healthier. In fact, those are things that you should do if you want to be healthier and lose weight. It’s possible that some of these efforts can interfere with GLP-1 medications or reduce their efficacy, but more research is necessary on this matter.
What If You Don’t Experience Weight Loss?
Sometimes, you may not experience weight loss immediately after starting GLP-1 medications. Some people have to take the medication for up to 12 weeks before seeing results. If you have doubts about this, or see that these medications are not moving the needle, consider speaking with your doctor or engage in some of the previously mentioned lifestyle changes.
You can also consider the Dherbs Full Body Cleanse, which is a 20-day program that has helped millions of people lose weight and experience better overall health. It outlines exactly what you need to do to succeed during the cleanse. Although a lot of people use the cleanse to lose weight (potential to lose 10 to 30 pounds during the 20-day cleanse), its main purpose is to cleanse the body’s major organs and systems. Using the Full Body Cleanse can help the pounds go down and improve overall health and wellness. Not to mention, it’s about one-tenth the cost of GLP-1 medications!
Vincent Stevens is the senior content writer at Dherbs. As a fitness and health and wellness enthusiast, he enjoys covering a variety of topics, including the latest health, fitness, beauty, and lifestyle trends. His goal is to inform people of different ways they can improve their overall health, which aligns with Dherbs’ core values. He received his bachelor’s degree in creative writing from the University of Redlands, graduating summa cum laude. He lives in Los Angeles, CA.
