Mounjaro, Ozempic, Wegovy, and countless other glucagon-like peptide-1 (GLP-1) medications are intended to help lower blood sugar levels. They work to trigger insulin release from the pancreas. Insulin lowers the amount of glucose in the blood, and insufficient insulin levels can cause blood sugar to increase and increase the risk of diabetes. That is not really why GLP-1 medications are so popular these days, though. People use these drugs to promote weight loss and control obesity.
Glucagon is a hormone that the body uses to elevate blood sugar levels when necessary. GLP-1 actually prevents glucose from entering the bloodstream. It also slows stomach emptying, which ultimately releases less glucose from the food you eat into the bloodstream. GLP-1 medications also affect the area of the brain that processes hunger and satiety. You basically feel full quicker after eating a smaller amount.
Given the popularity of these drugs, scientists question whether or not there is a natural way to tap into those same hunger- and fullness-pathways without drugs. A new review pulled emerging evidence on foods and plant compounds that may help support the body’s own GLP-1 activity. Just to be clear, though, these natural options are not replacements for medications. Early science does suggest that they may play a meaningful role in supporting appetite regulation and blood sugar balance.
The Science Behind Natural GLP-1 Modulation
The review was recently published in Toxicology Reports and included decades of data on how foods, herbs, and bioactive compounds influence GLP-1, the hormone that GLP-1 drugs are designed to mimic. The gut produces GLP-1 and it has several jobs, such as:
- Stimulating insulin release
- Slowing digestion so you can stay fuller for longer
- Signaling fullness to the brain
- Reducing blood sugar after meals
GLP-1 medications work so well, so is it even possible for natural substances to gently support similar pathways? In order to figure this out, researchers looked at the combined research of studies on spices, teas, plant polyphenols, and fermented foods to see which compounds consistently influenced GLP-1 release or activity. As of now, nothing works as powerfully as prescribed medications; however, some ingredients triggered increases in GLP-1 release, or at least improved the body’s sensitivity to it.
What The Researchers Found
According to the studies that researchers examined, the most natural GLP-1 supporters are as follows:
- Cinnamon extract
- Curcumin (from turmeric)
- Berberine
- Green tea and post-fermented tea compounds
- Wheat protein
- Ginger and gingerol
- Quercetin-rich plant foods (including apples, berries, cherries, onions, leafy greens, and grapes)
Researchers note that these natural GLP-1 modulators are not replacing existing medications. Instead, they want people to know that natural options exist. That helps because GLP-1 medications are not affordable or available to everyone. Some people also cannot tolerate the medications and experience intense side effects. Lastly, many people prefer nutrition-forward approaches to things. If you are looking to naturally support metabolic pathways, consider the ingredients we detailed. When paired with balanced nutrition and regular exercise, they may do wonders for your body.
Vincent Stevens is the senior content writer at Dherbs. As a fitness and health and wellness enthusiast, he enjoys covering a variety of topics, including the latest health, fitness, beauty, and lifestyle trends. His goal is to inform people of different ways they can improve their overall health, which aligns with Dherbs’ core values. He received his bachelor’s degree in creative writing from the University of Redlands, graduating summa cum laude. He lives in Los Angeles, CA.
