Longevity is a term that can refer to lifespan, or lifespan and health-span. The internet has no shortage of articles supplying you with tips and tricks that tell you how to increase your longevity. Truly, why not? Most people want to live longer, especially if there is a possibility to harness the vitality of younger years at an older age. Longevity also comes with a happiness bonus, as feeling and looking younger tends to make people a lot happier. 

A 2025 McKinsey report found that up to 60% of people regard healthy aging as a top priority. Many supplements claim to promote longevity or reverse aging, but that isn’t always the case. Many health experts are divided on what really works to promote longevity. Some experts believe that some supplements are more context-dependent, or depend on a person’s specific needs. Although the consensus for the perfect longevity supplement is not yet determined, health experts believe the following supplements may offer some help. 

Omega-3s

The research on omega-3s for longevity is limited, but some clinical trials suggest that they may slow biological aging (the age of cells) by up to four months. That is especially true when you take omega-3 supplements in conjunction with vitamin D and regular exercise. Omega-3s offer anti-inflammatory properties and support cardiovascular health. Most people do not get enough omega-3s in their diet, so supplementing may help meet daily requirements. Health experts note that although fish oil benefits healthy aging, it does not slow aging or offer longevity benefits. 

Vitamin D

Research confirms that low vitamin D levels can increase the risk of age-related illnesses, such as dementia, Alzheimer’s disease, cancer, and Parkinson’s disease. Daily supplementation with about 2,000 I.U. of vitamin D may help slow the way cells age. Considering nearly 40% of Americans are vitamin D deficient, a daily supplement may help longevity and overall health. At this time, the data and research is still emerging on whether or not vitamin D is beneficial for its longevity benefits. 

Magnesium

Low magnesium levels are more common in old age and may increase inflammation and free radical damage as a result. Both inflammation and an overabundance of free radicals are associated with age-related illness and the general aging process. Taking a magnesium supplement may help you maintain optimal magnesium levels, which can contribute to healthy aging. Some animal studies indicate that magnesium can improve longevity, but that research does not exist in humans yet. A magnesium supplement may benefit longevity because it is relatively low risk with positive data supporting its usage. 

Protein Supplements

Muscle loss is a natural part of the aging process, and that can affect physical function. It may also increase the risk of hospitalization (as a result of falling) and lead to loss of independence. Studies suggest that combining a protein supplement with an active lifestyle can help older adults build and retain muscle mass. Adding protein to your meal, especially plant protein, has been linked to a greater chance of healthy aging. People consume far less protein than they need to maintain or gain muscle mass. Although sarcopenia (age-related loss of muscle mass) is slow, silent, and it begins earlier than you think. 

Some longevity supplements are overhyped, especially resveratrol, ashwagandha, berberine, and NAD. Those supplements may help other aspects of your health, but there is little to no evidence that they improve mechanisms involved with aging and longevity.

Vincent Stevens

Vincent Stevens is the senior content writer at Dherbs. As a fitness and health and wellness enthusiast, he enjoys covering a variety of topics, including the latest health, fitness, beauty, and lifestyle trends. His goal is to inform people of different ways they can improve their overall health, which aligns with Dherbs’ core values. He received his bachelor’s degree in creative writing from the University of Redlands, graduating summa cum laude. He lives in Los Angeles, CA.