There are many semaglutide and tirzepatide (known commercially as Ozempic, Wegovy, Zepbound, and Mounjaro) on the market. These drugs target GLP-1 receptors and have been influential in the treatment of diabetes and obesity. Many people can experience dramatic weight loss and benefits for other chronic health conditions. At the same time, these medications come at a steep cost, which has prompted health economists to ask this question: are these drugs worth the price tag?

Two relatively recent studies have researchers questioning the use of GLP-1 drugs. Even though they have the potential to deliver impressive long-term health improvements, their current high price exceeds the accepted thresholds for cost-effective medications. That not only poses difficult choices for policymakers, but also insurers and patients. 

GLP-1 Drugs: A Pharmaceutical Breakthrough?

Before you start a medication, you should understand how it works. In a nutshell, GLP-1 drugs mimic hormones that regulate hunger and satiety. This process helps people feel full sooner, and they eat less as a result. During clinical trials, GLP-1 drugs have produced weight loss of 15-20%, a percentage range that far exceeds older medications. They don’t just help with weight loss; rather, they may also improve conditions like sleep apnea, chronic kidney disease, and cardiovascular disease. 

That’s a big deal when you consider that obesity increases your risk of developing all of those conditions. According to premature predictions, GLP-1 drugs could potentially prevent thousands of cases of diabetes and cardiovascular disease. That said, there are many natural and healthier ways to contribute to overall health and wellness. The Dherbs Full Body Cleanse is one such program that can help you cleanse the body’s major organs and systems in just 20 days. One of the added benefits is weight loss of 10 to 30 pounds, which is depending on underlying health conditions and body weight. 

Here’s Why The Math Doesn’t Add Up

You can say that GLP-1 drugs offer a range of health benefits, and they do for some people, but at what cost? Generally speaking, a person spends between $700 to $1,000 per month on GLP-1 drugs in the U.S. Accounting for long-term health benefits, researchers have found that these drugs fall short regarding cost effectiveness. 

In an optimistic scenario, researchers used the best weight loss outcomes and long-term risk reductions. Even in that situation, the GLP-1 drugs did not meet the cost effectiveness threshold. This threshold is usually defined as less than $100,000 per quality-adjusted life year (QALY), a standard tool that health economists use to compare medical treatments. One study found that there would have to be a 30% price reduction of tirzepatide to meet the standard mark. For semaglutide drugs, they would need to cost 80% less than what they currently do. 

It’s important to note that Medicare pays for these GLP-1 drugs only if they are prescribed for diabetes or, more recently, sleep apnea. If Medicare expanded coverage, nearly three million beneficiaries would start using drugs over the next decade. Health economists expect those drug costs to total $66 billion, with nearly $18 billion saved through reduced hospitalizations. So over the next 10 years, Medicare would spend $48 billion on these drugs alone. 

Looking For Smarter Solutions

There are many other affordable ways to see better results without having to inject yourself with GLP-1 drugs. Plus, if you want to continue to see results, you have to keep using the medications. It’s much better to develop healthy lifestyle habits and lose weight with a plan in place. Anyone can tell you to exercise regularly, eat better, and establish healthy sleep habits, but those are general recommendations. 

At Dherbs, we pride ourselves in our all-natural products, especially the Full Body Cleanse. This 20-day program has helped people transform their health, and lose between 10 to 30 pounds in the process! Some people cleanse once per year to reset their bodies, while others cleanse back to back until they reach their desired health goals. There are knowledgeable customer service reps and an entire website full of resources to help you succeed. Plus, it’s a fraction of the cost of those GLP-1 drugs! Cleanse today and that weight will melt away, and the results are noticeable within a week, depending on the body and underlying health issues.

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Ozempic is a prescription medication classified in a group of drugs known as glucagon-like peptide-1 (GLP-1). The active ingredient in Ozempic is semaglutide, which you administer once a week by subcutaneous injection (under the skin). This drug is approved by the Food and Drug Administration (FDA) for controlling blood glucose in people with type 2 diabetes. More recently, however, people have used Ozempic and similar drugs to promote weight loss. 

Due to the popularity of Ozempic and other GLP-1 drugs for weight loss, some healthcare providers offer off-label Ozempic. That is specific to overweight or obese people living with risk factors such as high blood pressure or high cholesterol. If you take Ozempic, you might be wondering how long it stays in your system. That is especially true if you experience some of the unfortunate side effects. 

Is there actually a way to help clear Ozempic from your body faster? It can take weeks for the medication to naturally leave the system, but there are certain strategies to manage effects as it leaves the body. Continue reading to learn more about that. 

How Long Does It Take For Ozempic To Leave Your Body?

Health experts note that it can take up to five weeks for the body to fully eliminate Ozempic. Unfortunately, there is no way to accelerate this process. Before you can understand how long it takes the body to eliminate Ozempic, it is helpful to know the drug’s half-life. Just like plutonium, coffee, or any other drug, Ozempic has a half-life. That is the amount of time it takes for half the drug to leave the body. The body eliminates some drugs faster than others, but generally speaking, it takes about five half-lives for a drug to be completely eradicated from the body.

Ozempic’s half-life is seven days, which means that it can take up to 35 days (five half-lives) for it to completely leave the body after the last dose was administered. The elimination process only begins after you administer the last dose of the medication. If you continue to take Ozempic, it will remain in your system and prolong the detoxification period. 

Can You Get It Out Of Your System Faster?

As previously stated, the elimination of a drug from your body follows a natural timeline determined by:

• The drug’s half-life
• Metabolism (the process by which the body breaks down the drug)
• Excretion (removal of the drug via urine or feces)

Generally speaking, there is no guaranteed or scientifically-backed way to expedite the removal process. For certain medications, you can receive specific antidotes or agents that can expedite the process. Narcan, for example, is a drug used to quickly reverse an opioid overdose. That is a specific situation and it does not apply to every drug or medication.

Basically, it is not possible to flush Ozempic out of your system faster than five to seven weeks. If you want to stop taking the GLP-1 drug, talk to your healthcare provider first. They will advise you on how to safely transition off the drug, which can help minimize side effects. The body will eliminate the drug at its own pace, but you should consult your healthcare provider if you are experiencing side effects or complications related to the medication. 

The Takeaway

If you want to stop taking Ozempic or other GLP-1 drugs, there are safe ways to transition off the medication without experiencing negative side effects. By making healthy lifestyle changes, you can help regain control of your health and feel more like yourself once you get off the drug. Want a little assistance resetting your body? Try the Full Body Cleanse, which is a 20-day herbal cleanse designed to rid the body of toxins and waste and cleanse the body’s major organs and systems.

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GLP-1 medications, such as Ozempic and Wegovy, have been referred to as weight loss “game-changers” or “miracles” for people living with obesity. A 2021 clinical trial found that 86.2% of more than 800 participants experienced significant weight loss after taking 2.4-milligram (mg) doses of semaglutide for 68 weeks. While that sounds promising, 13.8% of participants did not see clinically significant weight loss. 

When it comes to GLP-1 medications, health experts state that people fall into two camps: responder or non-responder. The former indicates that people positively respond to the medications and experience weight loss, while the later indicates that the medications have no effect on the person. Just like with other medications, one prescription is not a one-size-fits-all remedy for every single person. That is especially true for managing obesity. 

Doctors want to remind patients that there tends to be more than one reason why a person ends up in the responder or non-responder categories. Even though the drugs may seem ideal in clinical trials, they do not work for everyone. Just like other medications, they can be unpredictable, both in how they perform and how a person responds to them. Why is that the case? Continue reading to learn about five of the most common reasons, according to health experts. 

Existing Medical Issues

It’s possible for a person to have underlying medical issues that are either untreated, undertreated, or undiagnosed. Hypothyroidism, sleep apnea, and chronic insomnia, for example, can all interfere with weight loss. Those conditions should be dealt with prior to starting a weight loss journey, let alone a weight loss medication. Patients who have an issue with obesity and a binge eating disorder should also address the eating disorder prior to using GLP-1 medications. The binge eating disorder will not correct itself just because you take a GLP-1. 

Medication Interference

People who take GLP-1 drugs alongside other medications may experience less weight loss, or none at all. It’s common for people who take antidepressants and beta blockers to have a difficult time losing weight. Adding a GLP-1 drug to the mix will not encourage weight loss, though. It is better to speak to your healthcare provider about other medications prior to taking a GLP-1. 

Insulin Resistance 

Ozempic is a GLP-1 drug designed to help diabetics lower their A1C. According to a 2022 narrative review, though, people may lose less weight while taking GLP-1 medications. When you have a pre-existing metabolic disease, it can feel like an uphill battle to reverse those abnormalities, especially if you’ve lived with them for a long time. This is due to the physiological response. Typically, GLP-1 aids blood sugar control by stimulating the pancreas to release insulin after meals. That response may be less potent in individuals who do not have type 2 diabetes. The weakened response to GLP-1, then, can make it more difficult to manage blood sugar and lose weight, which can require alternative treatment methods. 

Lifestyle Changes

Trials for semaglutide have included lifestyle intervention for both placebo and medication groups. In a 2021 trial consisting of more than 1,900 adults, for example, researchers wanted to see what influenced the best response to a GLP-1 medication. The general recommendation was that patients should:

• Exercise regularly
• Manage stress
• Maintain a predominantly plant-based diet
• Get quality sleep
• Avoid substance use
• Keep strong social relationships with family and friends

Now, those recommendations are not novel in regards to losing weight and living healthier. In fact, those are things that you should do if you want to be healthier and lose weight. It’s possible that some of these efforts can interfere with GLP-1 medications or reduce their efficacy, but more research is necessary on this matter.

What If You Don’t Experience Weight Loss?

Sometimes, you may not experience weight loss immediately after starting GLP-1 medications. Some people have to take the medication for up to 12 weeks before seeing results. If you have doubts about this, or see that these medications are not moving the needle, consider speaking with your doctor or engage in some of the previously mentioned lifestyle changes. 

You can also consider the Dherbs Full Body Cleanse, which is a 20-day program that has helped millions of people lose weight and experience better overall health. It outlines exactly what you need to do to succeed during the cleanse. Although a lot of people use the cleanse to lose weight (potential to lose 10 to 30 pounds during the 20-day cleanse), its main purpose is to cleanse the body’s major organs and systems. Using the Full Body Cleanse can help the pounds go down and improve overall health and wellness. Not to mention, it’s about one-tenth the cost of GLP-1 medications!

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The before and after photos seem to captivate people. The success stories of the “miracle” weight loss solutions that are GLP-1 drugs have taken the country by storm. People who have struggled with weight loss for decades can now shed pounds using an injectable drug. Some medical professionals find the drugs great for patients they have counseled about their weight for years. Other healthcare professionals remain skeptical of these drugs. 

Within the last few years, people have seen breakthroughs in treatments for obesity, primarily due to semaglutide drugs like Ozempic and Wegovy, or tirzepatide drugs like Mounjaro and Zepbound. These drugs work by slowing down stomach-emptying and reducing appetite. A patient administers one injection per week. It should be noted that GLP-1 drugs are a class of medications intended for diabetics, as they help manage blood sugar levels. Only recently have they been popularized as weight loss medications. 

Statistically, people using these medications lose about 10% to 20% of their body weight. People who have cardiovascular disease and are overweight or obese can see a 20% reduction of adverse cardiac events while using the drugs. Being overweight or obese increases the risk of many health problems, including type 2 diabetes, heart disease, stroke, sleep apnea, arthritis, and more. Considering that nearly 40% of U.S. adults are obese (with another 30% being overweight), many doctors and patients have embraced these GLP-1 drugs with open arms.

Drugs Don’t Address The American Health Crisis

Many people have adopted these new medications, but a high percentage accept them without recognition of their limitations. There is a lack of long-term safety data in addition to the long list of potential side effects, including vomiting, nausea, and a handful of other complications. In fact, Ozempic is currently facing over $2 billion in lawsuits! Poison control centers have reported an increasing amount of calls relating to medication overdoses, which can cause extreme low blood sugar and similar symptoms, such as dizziness, confusion, and irritability. 

GLP-1 medications that people use for weight loss typically cost over $1,000 per month for each patient. More than 50% of employer insurance plants in the U.S., in addition to Medicare, do not cover these medications. The price tag is troubling when you consider that the U.S. spends more than the rest of the world in health care costs and faces big disparities within the health care system. The cost of the drugs is especially questionable when you consider the fact that you have to take them for a long time to prevent weight regain. Additionally, if you stop using the drugs, you typically gain the weight back because the effects wear off. 

Using these medications to treat everyone with obesity in the U.S. would bankrupt the country. Not only that, but it doesn’t cultivate the type of health and change that a lot of healthcare professionals would like to see in this country. Every single person has unbelievable access to ultra-processed, calorically-dense foods that contribute to weight gain. High levels of inactivity do not help the problem either. Plus, the multibillion-dollar pharmaceutical industry does not prioritize disease prevention. 

Lifestyle Change Is True Health

True health is not just about the number on the scale; rather, it is more about adopting healthy habits that support long-term change. For example, switch your focus from ultra-processed foods and incorporate more vegetables, fruits, whole grains, legumes, and lean proteins into your diet. True health is engaging in some sort of physical activity every day and getting restorative sleep at night. Perhaps you add some stress management techniques to your day with positive affirmations. 

You need a plan to start, though, as many people struggle to make change without an outline. Lifestyle changes are often affordable and low-risk. People who start to eat better, exercise more frequently, stop smoking, and manage stress can reduce their risk of coronary artery disease by over 80%. Finally, the risk of type 2 diabetes decreases by over 90% if these changes are made. 

Enter The Full Body Cleanse

The Dherbs Full Body Cleanse is an all-natural herbal cleanse accompanied by the raw vegan diet. Not only is this about one-tenth of the price of GLP-1 drugs, but it is also much healthier for the body. It is difficult, but it sets you on the right path to make long-term changes. Additionally, it’s possible to lose between 10-30 pounds during the 20-day cleanse, but that depends on how much weight the body has to lose and if you have underlying health conditions that inhibit weight loss. 

With GLP-1 drugs, you can lose an average of one to two pounds per week. It’s possible to lose more, but health experts suggest that that number is fairly accurate across the board. Unlike the Full Body Cleanse, GLP-1 drugs come with a long list of side effects. Not to mention, these drugs do not encourage people to change their lifestyle habits, which means that they can easily gain the weight back once they stop taking the drugs. 

The bottom line is that there is no magic pill or miracle drug for weight loss. It is better to teach the next generation to promote healthy behaviors and implement these practices in their own lives. Make the right choice, even if it is a little more difficult. Just because something is easy does not mean it is healthy for you. Do yourself and your health a favor and cleanse today!

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Ozempic, which is an injectable semaglutide, is one of the most popular type 2 diabetes drugs on the market. Within recent months, it has become more difficult to acquire because of how many people seek it out. There is one reason for the growing demand: dramatic weight loss, which is one of the common side effects. 

Wegovy, another drug and medicine, also contains semaglutide, which helps regulate blood sugar. Semaglutide helps people feel full and eat less because it curbs appetite and slows digestion in the stomach. Besides weight loss, other side effects of semaglutide include diarrhea, nausea, headaches, and constipation. 

Ozempic and Wegovy have been on the U.S. Food and Drug Administration (FDA) drug shortage list for several months. Although there are other type 2 diabetes medications that work in a similar fashion, they don’t induce weight loss in the same way. Because of the shortage and high out-of-pocket cost, many patients decided to stop taking Ozempic. How could they maintain the same weight loss they experienced while taking the medication? That depends on each person, but it’s also possible to experience the following things after stopping Ozempic. 

Appetite Returns

While taking Ozempic, people eat less because semaglutide slows digestion. That keeps food in the stomach for longer and increases feelings of fullness. Ozempic also trigger changes in the brain that actually reduce hunger and curb feelings of satisfaction that accompany eating. For example, you may only be able to eat a few bites of pizza while using semaglutide, whereas you could eat half a pizza prior to using it. That rapid feeling of fullness goes away as soon as you stop taking Ozempic, causing you to eat more, so following a low-calorie diet becomes very difficult. 

You’ll Regain Weight

When you stop feeling full and your appetite returns, the first thing that you reach for is more food. The unfortunate reality is that medication, like Ozempic shouldn’t be the only treatment plan for people with type 2 diabetes or obesity. Healthy lifestyle changes, such as a balanced diet and regular exercise, are necessary for long-term success and health. Without those lifestyle changes accompanying the use of Ozempic, users will most likely regain weight and suffer from poor blood sugar control.

Blood Sugar Climbs

For those with type 2 diabetes who take Ozempic to manage blood sugar, halting treatment may cause blood sugar to return to pre-medication levels. Endocrinologists explain that Ozempic treats the chronic disease of diabetes, so people can expect the condition to worsen once they stop using it. As previously explained, Ozempic helps people eat less, so stopping treatment may cause them to eat larger portions and more calories. All of that amounts to an increase in blood sugar. Even if people manage to control their eating habits once they stop taking Ozempic, blood sugar may still rise because the drug boosts insulin production, a hormone involved in blood sugar control.  

Ozempic Face Will Go Away

Experiencing rapid weight loss from Ozempic use can affect the skin and reduce fat all over the body, including the face. Ozempic users who lost dramatic amounts of weight reported that their faces appeared shrunken, dehydrated, and gaunt. Dubbed “Ozempic face,” this physical change is contingent with other instances of dramatic weight loss. Stopping Ozempic can reverse these facial changes, especially if users regain weight. If the face doesn’t return back to normal after stopping treatment, injectable facial fillers from a board-certified dermatologist or plastic surgeon can address the situation.

Side Effects Will Subside

In addition to weight loss, Ozempic users can experience nausea, constipation, vomiting, heartburn, gas, headaches, and dizziness. Not all users experience these side effects and some only experience mild versions of those side effects. How you eat and what you eat can also make a difference in whether you experience side effects or not. Reducing the consumption of dietary fat, consuming smaller portions, and not skipping meals can help reduce the chances of experiencing these side effects. Users that stuck with Ozempic treatment and still experienced those side effects would see them go away after stopping the medication.

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The back-to-school season is a time for new opportunities and beginnings. For some students, especially those with compromised immune systems, the susceptibility to illness increases. Protecting your child(ren) and yourself against common colds or other infections that circulate the classroom can be a lot easier with the right steps in place. 

Developing a back-to-school routine is a challenge in and of itself. Waking up earlier, establishing a quick and efficient routine, and leaving the house on time can prove difficult, especially after summer vacation. Many health officials state that immune health is tied to diet, sleep, and exercise. Building a healthy diet and establishing movement and proper sleep hygiene can enhance immune function, which your child needs as they face the new school year. Hopefully, the following tips can help better prepare your child’s immune system for the back-to-school reality.

Get Plenty Of Sleep

The Sleep Foundation encourages school kids between the ages of six and 13 to get nine to 11 hours of sleep every night. Without sufficient sleep, the body has a more difficult time regulating biological rhythms. Not to mention, insufficient sleep makes the body more susceptible to sickness. If you or your child has trouble sleeping, there are practices that have proven to be quite effective. Click here to learn more about methods that help you fall asleep.

Drink Water

Water is essential for a healthy life because it has many roles in the body. Not only does it help with waste elimination, but it also helps the immune system function optimally. If the body is in a dehydrated state, it cannot effectively produce white blood cells, which help fight off bacteria, pathogens, and viruses. Drinking plenty of water can also help flush toxins from the body, which keeps the immune system functioning optimally. Need help getting your kiddos to drink more water? Spice it up by adding fresh fruit to the water, or consider blending some fruit with water to make a healthier rendition of a punch.

Eat The Right Foods

Dietitians agree that one of the best ways to boost the immune system is to eat the right foods. Focus on fruits and vegetables because they are rich in vitamins, minerals, and antioxidants that boost the function of immune cells. High-fiber foods also work to maintain a healthy digestive system. What foods do you eat to encourage better immune function? Consider packing the following snacks in your child’s lunch: 

• Oranges: One orange can have up to 75% of the daily value (DV) of vitamin C. 
• Mandarins: Mandarins pack a considerable amount of vitamin C and make for the perfect lunch snack. They are easy to peel, easy to put in lunches, and their seedlessness makes them easy to enjoy!
• Sunflower seeds:  Make sure to opt for the unsalted, shell-less sunflower seeds because they are very easy to eat. Sunflower seeds are also rich in vitamin E, which exhibits antioxidant effects in the body. 
• Almonds: Similar to sunflower seeds, almonds are naturally rich in vitamin E, which helps to fight off free radicals and boost immune function. They also contain heart healthy fats, protein, and lots of fiber. 
• Broccoli: It may be very difficult to get your child to eat broccoli, but it is an excellent source of vitamin C and sulforaphane, both of which encourage immune function. Sneak broccoli into meals like broccoli tater tots or fruit smoothies!

Exercise Regularly

It’s no secret that kids like to run amok like they haven’t a care in the world. The important thing to remember is to not let your child immediately plop on the couch or bed and watch TV or play video games from the time they get home to the time they go to bed. Even if your child is active in school sports or playground activities, make sure they remain active outside of school hours. This is especially important as they progress through the year and the weather starts to cool off. 

Maintain A Healthy Weight

Childhood obesity is a serious problem in the United States, and it puts children and adolescents at risk for poor health. Between 2017-2020, 19.7% of children between the ages of two and 19 were affected by obesity. Obesity prevalence between two- and five-year-olds amounted to 20.7%, and 22.2% among six- to 11-year-olds. Data revealed that obesity prevalence was higher in Hispanic and non-Hispanic Black children than it was in non-Hispanic White children and non-Hispanic Asian children. Aside from decreased immune function, obesity increases the child’s risk of other health problems. Consult your family doctor if you notice the child’s weight is becoming a problem.

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Just four simple ingredients and a simple method required to make this luxurious and refreshing apricot sorbet. Because it is a no-churn sorbet, an ice cream maker is not required for this recipe. You just need a food processor, a freezer-safe container, and a desire to enjoy a subtly sweet and tart sorbet. We love this sorbet because it is creamy, sweet, tart, refreshing, and made with simple methods.

Apricots are stone fruits that are in season during summer. They are low in calories and have a diverse nutritional profile. They contain vitamins, A, C & E, potassium, fiber, and powerful carotenoids, including zeaxanthin, beta-carotene, and lutein. Apricots also other flavonoids that may help the body fight off illnesses, including type 2 diabetes and heart disease. The primary flavonoids in apricots are catechins, chlorogenic acids, and quercetin. Working to neutralize free radicals and oxidative stress, these flavonoids may help reduce the risk of chronic illnesses and obesity. Do not peel your apricots because the peel boasts large quantities of fiber and other nutrients. Just make sure that you discard the pit (a.k.a. the stone), as that is inedible.

The best way to ensure that this sorbet has a great texture is to freeze the apricots ahead of blending them with the other ingredients. Just make sure to separate the slices to avoid them freezing in giant clumps. You can do this by laying them flat on a parchment paper-lined plate or baking tray. Once they are frozen, you can use them immediately to make the sorbet, or you can store them in a freezer bag or airtight container in the freezer until you are ready.

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Berberine is a naturally occurring compound in many plants. For thousands of years, it has been used in Traditional Chinese Medicine (TCM), Ayurveda, and other medicinal traditions to treat digestive disorders, inflammatory conditions, and infections. Some research indicates that it may offer protection against high blood pressure, diabetes, and high cholesterol, among other conditions. 

What Is Berberine?

Extracted from several plants, berberine is a bioactive compound that belongs to the alkaloid class. It is yellow and typically used as a dye, despite its long history in traditional medicinal applications. Modern evidence suggests that it exhibits impressive health benefits that may address chronic conditions. As of now, limited human research indicates that berberine may lower cholesterol, triglycerides, and blood sugar levels. This is of great interest to the health experts because these are reversible risk factors for heart disease. Although it appears to be safe and only causes a few mild side effects, you may want to consult a healthcare professional if you are interested in taking it. 

How Does Berberine Work?

There have been hundreds of studies on berberine’s effects on the body. According to animal studies, one of berberine’s primary actions is to activate AMP-activated protein kinase (AMPK), an enzyme inside cells. Found in cells throughout the body, AMPK has an active role in regulating metabolism and energy levels. Berberine also has an effect on other molecules inside cells, potentially affecting which genes are turned on or off. That may help protect against many chronic health conditions, but more research is necessary on this matter. Continue reading to learn more about berberine’s health benefits. 

May Protect Against Bacterial Infections

A 2022 study found that berberine helped prevent the growth of Staphylococcus aureus. Researchers note that this bacterial strain can cause sepsis, pneumonia, meningitis, and a range of skin conditions. Another study found that berberine exhibited an ability to damage the DNA and protein of certain bacteria, due to its antimicrobial activity. 

It Helps Lower Blood Sugar Levels

According to many studies, berberine can significantly lower blood sugar levels in people with type 2 diabetes. In 2008, study authors monitored a group of 116 participants who took one gram of berberine per day. The results indicated that berberine lowered fasting blood sugar by 20%, and it also lowered hemoglobin A1c (HbA1c) by 12%. Additionally, berberine improved blood lipids, including cholesterol and triglycerides. Researchers note that berberine seems to work in several ways to aid these processes:

• Decreases sugar production in the liver
• Reduces insulin resistance to make insulin more effective
• Increases the amount of beneficial bacteria in the gut
• Slows the breakdown of carbohydrates in the gut
• Increases glycolysis, which helps the body break down sugars inside cells

May Aid Weight Loss

There is a lot of attention on berberine because it may be a viable weight loss supplement. An older 12-week study involved people with obesity who took 500 milligrams (mg) of berberine three times daily. At the end of the study, participants experienced five pounds of weight loss, on average, with a 3.6% reduction in body fat. A review of 12 studies noted that supplementing with berberine led to significant reductionist body weight, belly fat, and body mass index. It was also effective at decreasing C-reactive protein, a marker of inflammation. Other research found that berberine works to inhibit the growth of fat cells at a molecular level, which may promote weight loss. Although existing research is promising, more research is necessary to determine berberine’s weight loss effects.

It Helps Lower Cholesterol

If you have high levels of triglycerides and LDL cholesterol, you have a higher risk of heart disease and stroke. Some research suggests that berberine may help lower LDL cholesterol and triglyceride levels. One review of both animal and human studies found that berberine exhibits cholesterol lowering effects. Researchers believe that berberine’s effects are similar to drugs that reduce high cholesterol. The only difference is that berberine does not cause the same side effects. 

May Benefit People With Obesity

There is an obesity epidemic in the United States, and it increases a person’s risk of type 2 diabetes, heart disease, high cholesterol, and high blood pressure. One review found that people who took 750 mg of berberine twice daily for three months experienced significant weight loss. Another double-blind study monitored people with metabolic syndrome who took 200 mg of berberine three times daily. Participants experience decreases in their body mass index scores. Finally, some research suggests that berberine works similarly to metformin, a drug that doctors typically prescribe people with type 2 diabetes. Additionally, berberine works to alter gut bacteria, which may benefit people with diabetes and obesity.

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A lot of people, especially overweight people, turn to diet soda to reduce their caloric intake. The appeal is that it is a sugar-free, carb-free, fat-free, zero-calorie beverage. It does, however, contain aspartame, which is about 200 times sweeter than regular sugar. So why is it that a calorie-free drink makes you hungrier?

Let’s remove diet soda from the equation for just a moment. It stands to reason that if you are hungry, you eat something and the hunger goes away. Unfortunately, it isn’t that simple. You have more than likely eaten meals that fill you up more than others, even if you’ve eaten the same amount of food. For example, you go back for chow mein when you’ve already had a full serving. 

Sometimes, it’s not the nutrient density (or lack of nutrients) of the meal that gets in the way of satiating you. It can often be the beverage you drink alongside your meal. A new study found that non-caloric sweeteners that are typically found in diet sodas interfere with the brain’s hunger responses. Basically, these sweeteners make it more difficult for the brain to discern if you are actually full or not. They may even make you feel hungrier. 

How Do Non-Caloric Sweeteners Mess With Hunger Cues?

Aspartame, sucralose, stevia, and erythritol are the most popular sugar substitutes used in diet sodas and some low-calorie processed foods. Unlike regular sugar, these substitutes do not add additional calories. The problem is that consuming these types of sweeteners confuses the brain. In an ideal situation, the brain perceives calories coming in when you consume a food or beverage. That isn’t the case with diet soda, so the brain increases appetite in order to obtain other calories. 

To put it in simpler terms, non-caloric sweeteners confuse the brain. The body is programmed to expect some calories when it consumes something sweet. Zero-calorie sweeteners do not fulfill that expectation, so that mismatch stimulates the brain’s hunger cues and you end up eating more than you normally would as a result. 

Although artificial sweeteners can confuse hunger cues for every person, some people don’t experience as severe an effect as others. During the study, researchers noted that men and women with obesity had a heightened response to non-caloric sweeteners. The difference in reactions between people with obesity and people without obesity was quite evident. People with obesity had a very strong response in the hypothalamus, the part of the brain that regulates hunger. If people with obesity drink diet soda, they are more likely to overeat than people without obesity who drink diet soda. 

How To Better Understand Hunger Cues

Why do people with obesity experience a greater impact? Researchers don’t exactly know at the moment, but they suspect it to be a consequence of obesity. Being overweight is just the tip of the iceberg regarding obesity. Many bodily functions and processes influence how a person responds to food. The only thing you can do to fight back is to better understand the body’s hunger cues. 

All dietitians and researchers recommend avoiding diet sodas and other non-caloric sweeteners whenever possible. Ideally, avoid sugar as well, but it can be difficult to do that. Sugar consumption is linked to weight gain, but so is non-caloric sweetener consumption. Hunger and thirst are also easily confused. The body sometimes sends the same signals for hunger and thirst, due to overlapping mechanisms. This can result in unnecessary snacking, so with that in mind, make sure you maintain proper hydration levels.

If you feel hungry all the time, you most likely are not consuming satiating nutrients, including protein, healthy fats, fiber, and complex carbohydrates. Focusing on foods that contain these nutrients, such as whole grains, fruits, vegetables, legumes, nuts, and seeds, can help you get more of those nutrients. Practice mindful eating, chewing each bite slowly to savor the flavors. Additionally, try to have a dedicated space for eating and don’t sit on the couch, for example, as that can cause mindless eating, so you’ll consume more than you need to without realizing it.

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It’s no secret that cases of Alzheimer’s disease and dementia are on the rise. In fact, data from 2022 found that nearly 10% of American adults ages 65 and older have dementia. Another 22% experience mild cognitive impairment. An even more unsettling fact is that dementia cases are projected to double by the year 2060. That means that new dementia cases will rise to reach one million per year. 

Researchers note that the current lifetime risk of developing dementia after age 55 is 42%. Women face an even higher likelihood due to their longer life expectancy. Although aging is the dominant risk factor at the moment, health conditions including hypertension, poor mental health, obesity, and diabetes can contribute to the rising crisis. These projections are grim, but there are things you can do to delay, or at least reduce, your risk of developing dementia. A recent study, however, found that there is one promising solution to delaying the onset of dementia: staying socially engaged. 

Late-life Social Activity Could Delay Dementia Onset By Five Years

The recent study of conversation was published in Alzheimer’s & Dementia: The Journal of Alzheimer’s Association. It highlighted how frequent social interactions could help preserve cognitive health into old age. The study involved about 2,000 older adults for a period of nearly six to seven years. Researchers tracked their social engagement and cognitive status. 

The results indicated that those who were the most socially active delayed the onset of dementia by five years compared to those with minimal social interactions. Study authors also observed a lower risk of mild cognitive impairment, which is an early stage of memory decline. More specifically, study authors found that the participants who were more socially engaged had: 

• A 38% lower risk of developing dementia
• A 21% lower risk of mild cognitive impairment

These findings highlight the role that social connections play in maintaining brain health. More importantly, social connections may reduce the national burden of cognitive decline. 

How Does Socializing Benefit The Brain?

According to study authors, the mechanisms behind this brain boost are not fully understood yet. At the moment, researchers put forth the following theories:

• Stress reduction: Having positive social interactions on a regular basis can help reduce chronic stress, which can harm the brain. Lowering your stress levels can help protect the hippocampus, which is the region of the brain that is essential for memory.
• Cognitive stimulation: Social interaction not only provides mental challenges, but also diverse conversations that can promote new neural connections, a process called neurogenesis. This is integral to delaying the onset of dementia, considering that altered neurogenesis has been identified in Alzheimer’s and dementia patients. 
• Physical activity: More often than not, social interactions are typically coupled with some sort of movement. You may have a lunch date, which involves sitting, but you can take a walk or engage in a yoga class with a friend as well. Incorporating more movement into your social interactions can help protect against cognitive decline. 
• Hormonal balance: According to research, social engagement helps regulate the hypothalamic-pituitary-adrenal (HPA) axis. This helps control stress responses and can influence overall brain health. 

What Can You Do?

If you want to stay socially engaged as you age, you don’t have to make tremendous alterations to your life. A few simple ideas can help foster new social connections, and a few examples are:

• Volunteer: Giving back to the community is a great way to meet new people in your community. Not only that, but it provides a sense of purpose!
• Keep learning: Perhaps there is something you want to learn, and your age shouldn’t stop you from doing that. Enroll in a course or attend a workshop that encourages learning and interaction. 
• Join a club: This could be a book club, gardening group, or local ceramics class. These classes  harbor people with shared interests, which usually ignite conversations and connections. 
• Stay physically active: It’s no secret that exercise offers brain-boosting benefits. Rather than just working out by yourself, though, health experts encourage you to take fitness classes or join a physically active group to get the social and physical benefits.

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