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The food combining chart is a suggestion for "optimal" digestion. It suggests we should eat mono meals optimally. This is often impossible and there is no evidence scientifically for this method. I am not sure how it would be studied anyway. It is considered best to try to adhere to the rules to the best of your ability. However, mixing fruits and veggies as in a green smoothie is absolutely fine. The benefits of the nutrition you receive will out weigh any digestive disturbance that may occur. Feel safe to have green smoothies in your diet and cleanse. Hope this answers your question!